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Glutathione synthetase deficiency has been incriminated as the cause of chronic hemolytic anemia alone (due to isolated RBC enzyme deficiency) and as the cause of a generalized syndrome (due to enzyme deficiency in many tissues) characterized by mild hemolytic disease, severe metabolic acidosis, and mental deterioration

4.9 Addressing publication bias and negative outcomes While the majority of studies cited in this review report positive findings regarding the effects of natural compounds in AD models, the potential influence of publication bias must be acknowledged

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1164 Diets high in fiber and low in saturated fats help control chronic inflammation, improve lipid and glucose metabolism, thereby reducing the risk of cardiovascular diseases

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